2021 Joint UCLA SCORE Symposium

Sex Differences in Brain-Gut Disorders and Metabolism


Friday, March 19, 2021
9:00 AM – 3:15 PM PT

Symposium Program

Poster Competition Winners

Early Career Group

Two tied for First Place

Rachel Sarnoff, MD – “Brain-Gut Microbiome Differences between Constipation-Predominant IBS vs Non-Constipation Predominant IBS”

Carrie Wise, PhD – “Kdm5c Gene Dosage Determines Sex Differences in Adiposity”

Student Group

First Place
Rozeta Avetisyan – “X-Linked Kdm5c Gene Dosage in Preadipocytes In Vivo Influences Adiposity and Food Intake”

Second Place
Soumya Ravichandran – “Alterations in Reward network Functional Connectivity are Associated with Increased Food Addiction in Obese Individuals”

About the UCLA Specialized Centers of Research Excellence (SCORE) on Sex Differences

UCLA SCORE on Sex Related Differences in Brain Gut Microbiome Interactions in Irritable Bowel Syndrome. The aims are to gain a better understanding of the role of the gut microbiome and female sex hormones in the modulation of brain gut microbiome interactions in two of the most common disorders of the gastrointestinal tract, irritable bowel syndrome (IBS) and chronic functional constipation. These studies will provide valuable insights on the pathophysiology and treatment of these conditions. uclacns.org/score

UCLA SCORE on Sex Related Differences in Metabolism. The objective is to elucidate sex differences in risk factors and treatments for Metabolic Syndrome (MetSyn) components such as obesity, insulin resistance/diabetes, dyslipidemia, and fatty liver. Differences between men and women in susceptibility to cardio-metabolic disease are well known, but the underlying genetic and physiological mechanisms remain poorly defined. Our goal is to identify factors that determine sex-specific MetSyn risk, which may lead to better diagnosis and treatment for both sexes. sexdifferencesinmetabolism.ucla.edu