SCORE Publications

2024

Dong TS, Mayer E. Advances in Brain-Gut-Microbiome Interactions: A Comprehensive Update on Signaling Mechanisms, Disorders, and Therapeutic Implications. Cell Mol Gastroenterol Hepatol. 2024 Feb 7:S2352-345X(24)00027-4. doi: 10.1016/j.jcmgh.2024.01.024. Epub ahead of print. PMID: 38336171.

Ross FC, Mayer DE, Gupta A, Gill CIR, Del Rio D, Cryan JF, Lavelle A, Ross RP, Stanton C, Mayer EA. Existing and Future Strategies to Manipulate the Gut Microbiota With Diet as a Potential Adjuvant Treatment for Psychiatric Disorders. Biol Psychiatry. 2024 Feb 15;95(4):348-360. doi: 10.1016/j.biopsych.2023.10.018. Epub 2023 Oct 31. PMID: 37918459.

2023

Sarnoff RP, Osadchiy V, Dong T, Bhatt RR, Labus JS, Kilpatrick LA, Chen Z, Subramayan V, Zhang Y, Ellingson B, Naliboff B, Chang L, Mayer EA, Gupta A. A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits. Neuropharmacology. 2023 Mar 1;225:109381. doi: 10.1016/j.neuropharm.2022.109381. Epub 2022 Dec 17. PMID: 36539012; PMC10711989

Kilpatrick LA, Gupta A, Tillisch K, Labus JS, Naliboff BD, Mayer EA, Chang L. Neural correlates of perceived and relative resilience in male and female patients with irritable bowel syndrome. Neurogastroenterol Motil. 2024 Feb;36(2):e14710. doi: 10.1111/nmo.14710. Epub 2023 Nov 29. PMID: 38031358. *Equal contribution as senior author. PMC pending

Chang L, Gupta A, Naliboff BD, Labus J, Kilpatrick LA, Mayer EA. Maximizing Training and Mentorship in Sex as a Biological Variable Research Across Different Brain-Body Disorders. J Womens Health (Larchmt). 2023 Aug;32(8):869-876. PMC10457633

Jacobs JP, Lagishetty V, Hauer MC, Labus JS, Dong TS, Toma R, Vuyisich M, Naliboff BD, Lackner JM, Gupta A, Tillisch K, Mayer EA. Multi-omics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes. Microbiome. 2023 Jan 10;11 PMID: 3662453.

Sarnoff RP, Bhatt RR, Osadchiy V, Dong T, Labus JS, Kilpatrick LA, Chen Z, Subramanyam V, Zhang Y, Ellingson BM, Naliboff B, Chang L, Mayer EA, Gupta A. A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits. Neuropharmacology. 2023 Mar 1;225:109381. doi: 10.1016/j.neuropharm.2022.109381. Epub 2022 Dec 17. PMID: 36539012

Labus JS, Wang C, Mayer EA, Gupta A, Oughourlian T, Kilpatrick L, Tillisch K, Chang L, Naliboff B, Ellingson BM. Sex-specific brain microstructural reorganization in irritable bowel syndrome. Pain. 2023 Feb 1;164(2):292-304. doi: 10.1097/j.pain.0000000000002699. Epub 2022 May 25. PMID: 35639426

2022

Wang C, Kutch JJ, Labus JS, Yang CC, Harris RE, Mayer EA, Ellingson BM. Reproducible Microstructural Changes in the Brain Associated With the Presence and Severity of Urologic Chronic Pelvic Pain Syndrome (UCPPS): A 3-Year Longitudinal Diffusion Tensor Imaging Study From the MAPP Network. J Pain. 2023 Apr;24(4):627-642. doi: 10.1016/j.jpain.2022.11.008. Epub 2022 Nov 23. PMID: 36435486; PMCID: PMC10676766.

2021

Oughourlian TC, Wang C, Salamon N, Holly LT, Ellingson BM. Sex-Dependent Cortical Volume Changes in Patients with Degenerative Cervical Myelopathy. J Clin Med. 2021 Sep 1;10(17):3965. doi: 10.3390/jcm10173965. PMID: 34501413; PMCID: PMC8432178.

Oughourlian TC, Wang C, Salamon N, Holly LT, Ellingson BM, Sex-dependent spatial variation in cortical volume in patients with degenerative cervical myelopathy, Society for Neuroscience (SfN) Annual Meeting. November 3-7, 2021. Virtual presentation.

Labus JS, Wang C, Vora P, Liu C, Stains J, Gupta A, Mayer E, Ellingson B. Sex-specific Differences in Brainstem Microstructure in Chronic Visceral pain. Joint UCLA SCORE Symposium, March 2021.

2020

Lenhart A, Naliboff B, Shih W, Gupta A, Tillisch K, Liu C, Mayer EA, Chang L. Postmenopausal women with irritable bowel syndrome (IBS) have more severe symptoms than premenopausal women with IBS. Neurogastroenterol Motil. 2020 May 29;:e13913. doi: 10.1111/nmo.13913. [Epub ahead of print] PubMed PMID: 32469130; NIHMSID:NIHMS1606379.

Dong TS, Mayer EA, Osadchiy V, Chang C, Katzka W, Lagishetty V, Gonzalez K, Kalani A, Stains J, Jacobs JP, Longo VD, Gupta A. A Distinct Brain-Gut-Microbiome Profile Exists for Females with Obesity and Food Addiction. Obesity (Silver Spring). 2020 Aug;28(8):1477-1486. doi: 10.1002/oby.22870. PubMed PMID: 32935533; PubMed Central PMCID: PMC7494955.

Rahal H, Videlock EJ, Icenhour A, Shih W, Naliboff B, Gupta A, Mayer EA, Chang L. Importance of trauma-related fear in patients with irritable bowel syndrome and early adverse life events. Neurogastroenterol Motil. 2020 Sep;32(9):e13896. doi: 10.1111/nmo.13896. Epub 2020 Jun 17. PubMed PMID: 32558017; PubMed Central PMCID: PMC7483907

2019

Labus JS, Osadchiy V, Hsiao EY, Tap J, Derrien M, Gupta A, Le Nevé B, Grinsvall C, Öhman L, Törnblom H, Simren M, Mayer EA. Association of Gut Microbial Clostridia with Brain Functional Connectivity and GI Sensorimotor Function in Irritable Bowel Syndrome: A Tripartite Network Analysis. Microbiome 2019

Labus JS, Osadchiy V, Hsiao EY, Tap J, Derrien M, Gupta A, Tillisch K, Le Nevé B, Grinsvall C, Ljungberg M, Öhman L, Törnblom H, Simren M, Mayer EA. Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis. Microbiome. 2019 Mar 21;7(1):45. doi: 10.1186/s40168-019-0656-z. PubMed PMID: 30898151; PubMed Central PMCID: PMC6429755.

Addante R, Naliboff B, Shih W, Presson AP, Tillisch K, Mayer EA, Chang L. Predictors of Health-related Quality of Life in Irritable Bowel Syndrome Patients Compared With Healthy Individuals. J Clin Gastroenterol. 2019 Apr;53(4):e142-e149. doi: 10.1097/MCG.0000000000000978. PubMed PMID: 29351154; PubMed Central PMCID: PMC6051929.

Wang Z, Guo Y, Mayer EA, Holschneider DP. Sex differences in insular functional connectivity in response to noxious visceral stimulation in rats. Brain Res. 2019 Aug 15;1717:15-26. doi: 10.1016/j.brainres.2019.04.005. Epub 2019 Apr 8. PubMed PMID: 30974090; PubMed Central PMCID: PMC6711370.

Mayer EA, Labus J, Aziz Q, Tracey I, Kilpatrick L, Elsenbruch S, Schweinhardt P, Van Oudenhove L, Borsook D. Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report. Gut. 2019 Sep;68(9):1701-1715. doi: 10.1136/gutjnl-2019-318308. Epub 2019 Jun 7. Review. PubMed PMID: 31175206; PubMed Central PMCID: PMC6999847.

Davydov DM, Shahabi L, Naliboff B. Cardiovascular phenotyping for personalized lifestyle treatments of chronic abdominal pain in Irritable Bowel Syndrome: A randomized pilot study. Neurogastroenterol Motil. 2019 Dec;31(12):e13710. doi: 10.1111/nmo.13710. Epub 2019 Aug 20. PubMed PMID: 31429514; PubMed Central PMCID: PMC6861616.

Bhatt RR, Gupta A, Mayer EA, Zeltzer LK. Chronic pain in children: structural and resting-state functional brain imaging within a developmental perspective. Pediatr Res. 2019 Dec 2;. doi: 10.1038/s41390-019-0689-9. [Epub ahead of print] Review. PubMed PMID: 31791045; PubMed Central PMCID: PMC7263945.

Wang Z, Guo Y, Mayer EA, Holschneider DP. Sex differences in insular frontal connectivity in response to noxious visceral stimulation in rats. Brain Res. 2019; 1717:15-26; Epub April 8 2019; PMID: 30974090

2018

Gupta A, Mayer EA, Labus JS, Bhatt RR, Ju T, Love A, Bal A, Tillisch K, Naliboff B, Sanmiguel CP, Kilpatrick LA. Sex Commonalities and Differences in Obesity-Related Alterations in Intrinsic Brain Activity and Connectivity. Obesity (Silver Spring, Md). 2018;26(2):340-50. Epub 2017/12/28. doi: 10.1002/oby.22060. PubMed PMID: 29280306; PMCID: PMC5783781.

Addante R, Naliboff B, Shih W, Presson AP, Tillisch K, Mayer EA, Chang L. Predictors of Health-related Quality of Life in Irritable Bowel Syndrome Patients Compared With Healthy Individuals. J Clin Gastroenterol. 2018 Jan 18. doi: 10.1097/MCG.0000000000000978. [Epub ahead of print] PubMed PMID: 29351154; PMCID: PMC6051929.

Mayer EA. The Role of Gut-Brain Interactions in Influencing Symptoms of Irritable Bowel Syndrome. Gastroenterol Hepatol (N Y). 2018 Jan;14(1):44-46. PubMed PMID: 29491761; PMCID: PMC5824595.

Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G140-G157. doi: 10.1152/ajpgi.00288.2017. Epub 2018 Mar 22. PubMed PMID: 29565640; PMCID: PMC6109711.

Martin CR, Osadchiy V, Kalani A, Mayer EA. The Brain-Gut-Microbiome Axis. Cell Mol Gastroenterol Hepatol. 2018 Apr 12;6(2):133-148. doi: 10.1016/j.jcmgh.2018.04.003. eCollection 2018. Review. PubMed PMID: 30023410; PMCID: PMC6047317.

Osadchiy V, Labus JS, Gupta A, Jacobs J, Ashe-McNalley C, Hsiao EY, Mayer EA. Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects. PLoS One. 2018 Aug 6;13(8):e0201772. doi: 10.1371/journal.pone.0201772. eCollection 2018. PubMed PMID: 30080865; PMCID: PMC6078307.

Osadchiy V, Martin CR, Mayer EA. The Gut-Brain Axis and the Microbiome: Mechanisms and Clinical Implications. Clin Gastroenterol Hepatol. 2019 Jan;17(2):322-332. doi: 10.1016/j.cgh.2018.10.002. Epub 2018 Oct 4. Review. PubMed PMID: 30292888.

Ju T, Naliboff BD, Shih W, Presson AP, Liu C, Gupta A, Mayer EA, Chang L. Risk and Protective Factors Related to Early Adverse Life Events in Irritable Bowel Syndrome. J Clin Gastroenterol. 2018 Dec 19. doi: 10.1097/MCG.0000000000001153. [Epub ahead of print] PubMed PMID: 30575634.

Parker CH, Naliboff BD, Shih W, Presson AP, Videlock EJ, Mayer EA, Chang L. Negative Events During Adulthood are Associated With Symptom Severity and Altered Stress Response in Patients With Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. 2019 Jan 4. pii: S1542-3565(19)30002-3. doi: 10.1016/j.cgh.2018.12.029. [Epub ahead of print] PubMed PMID: 30616026.

Witt ST, Bednarska O, Keita ÅV, Icenhour A, Jones MP, Elsenbruch S, Söderholm JD, Engström M, Mayer EA, Walter S. Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome. Neuroimage Clin. 2018 Nov 17. pii: S2213-1582(18)30350-4. doi: 10.1016/j.nicl.2018.11.012. [Epub ahead of print] PMID: 30472166

2017

Coveleskie K, Kilpatrick LA, Gupta A, Stains J, Connolly L, Labus JS, Sanmiguel C, Mayer EA. The Effect of the GLP-1 analogue Exenatide on Functional Connectivity within the Homeostatic Network in Lean and Obese Women. Obesity Science and Practice. 2017. 3(4): 434-445. PMCID: PMC5729499.

Gupta A, Mayer EA, Acosta JR, Hamadani K, Torgerson C, van Horn JD, Chang L, Naliboff B, Tillisch K, Labus JS. Early adverse life events are associated with altered brain network architecture in a sex- dependent manner. Neurobiology of stress. 2017;7:16-26. Epub 2017/02/28. doi: 10.1016/j.ynstr.2017.02.003. PubMed PMID: 28239631; PMCID: PMC5318542.

Gupta A, Mayer EA, Fling C, Labus JS, Naliboff BD, Hong JY, Kilpatrick LA. Sex-based differences in brain alterations across chronic pain conditions. Journal of neuroscience research. 2017;95(1-2):604-16. Epub 2016/11/22. doi: 10.1002/jnr.23856. PubMed PMID: 27870423; PMCID: PMC5120652.

Gupta A, Mayer EA, Hamadani K, Bhatt R, Fling C, Alaverdyan M, Torgerson C, Ashe-McNalley C, Van Horn JD, Naliboff B, Tillisch K, Sanmiguel CP, Labus JS. Sex differences in the influence of body mass index on anatomical architecture of brain networks. International journal of obesity (2005). 2017;41(8):1185-95. Epub 2017/04/01. doi: 10.1038/ijo.2017.86. PubMed PMID: 28360430; PMCID: PMC5548596.

Moussaoui N, Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Tache Y. Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. Journal of neurogastroenterology and motility. 2017;23(1):135-43. Epub 2016/11/11. doi: 10.5056/jnm16105. PubMed PMID: 27829577; PMCID: PMC5216644.

Sanmiguel CP, Jacobs J, Gupta A, Ju T, Stains J, Coveleskie K, Lagishetty V, Balioukova A, Chen Y, Dutson E, Mayer EA, Labus JS. Surgically Induced Changes in Gut Microbiome and Hedonic Eating as Related to Weight Loss. Psychosomatic medicine. 2017;79(8):880-7. doi: 10.1097/psy.0000000000000494.

Tillisch K, Mayer EA, Gupta A, Gill Z, Brazeilles R, Le Nevé B, van Hylckama Vlieg JET, Guyonnet D, Derrien M, Labus JS. Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women. Psychosomatic medicine. 2017;79(8):905-13. doi: 10.1097/psy.0000000000000493.

Wang L, Goebel-Stengel M, Yuan PQ, Stengel A, Tache Y. Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones. Biology of sex differences. 2017;8:2. Epub 2017/01/20. doi: 10.1186/s13293-016-0122-6. PubMed PMID: 28101317; PMCID: PMC5237138.

2016

Gupta A, Labus J, Kilpatrick LA, Bonyadi M, Ashe-McNalley C, Heendeniya N, Bradesi S, Chang L, Mayer EA. Interactions of early adversity with stress-related gene polymorphisms impact regional brain structure in females. Brain structure & function. 2016;221(3):1667-79. Epub 2015/01/30. doi: 10.1007/s00429-015-0996-9. PubMed PMID: 25630611; PMCID: PMC4573367.

Labus JS, Naliboff B, Kilpatrick L, Liu C, Ashe-McNalley C, dos Santos IR, Alaverdyan M, Woodworth D, Gupta A, Ellingson BM, Tillisch K, Mayer EA. Pain and Interoception Imaging Network (PAIN): A multimodal, multisite, brain-imaging repository for chronic somatic and visceral pain disorders. NeuroImage. 2016;124(Pt B):1232-7. Epub 2015/04/23. doi: 10.1016/j.neuroimage.2015.04.018. PubMed PMID: 25902408; PMCID: PMC4627849.

Latorre R, Huynh J, Mazzoni M, Gupta A, Bonora E, Clavenzani P, Chang L, Mayer EA, De Giorgio R, Sternini C. Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects. PloS one. 2016;11(2):e0147468. Epub 2016/02/13. doi: 10.1371/journal.pone.0147468. PubMed PMID: 26866366; PMCID: PMC4750998.

2015

Coveleskie K, Gupta A, Kilpatrick LA, Mayer ED, Ashe-McNalley C, Stains J, Labus JS, Mayer EA. Altered functional connectivity within the central reward network in overweight and obese women. Nutrition & diabetes. 2015;5:e148. Epub 2015/01/20. doi: 10.1038/nutd.2014.45. PubMed PMID: 25599560; PMCID: PMC4314578.

Gupta A, Mayer EA, Sanmiguel CP, Van Horn JD, Woodworth D, Ellingson BM, Fling C, Love A, Tillisch K, Labus JS. Patterns of brain structural connectivity differentiate normal weight from overweight subjects. NeuroImage Clinical. 2015;7:506-17. Epub 2015/03/05. doi: 10.1016/j.nicl.2015.01.005. PubMed PMID: 25737959; PMCID: PMC4338207.

Kilpatrick LA, Istrin JJ, Gupta A, Naliboff BD, Tillisch K, Labus JS, Mayer EA. Sex commonalities and differences in the relationship between resilient personality and the intrinsic connectivity of the salience and default mode networks. Biological psychology. 2015;112:107-15. Epub 2015/10/07. doi: 10.1016/j.biopsycho.2015.09.010. PubMed PMID: 26440126; PMCID: PMC5012423.

Labus JS, Van Horn JD, Gupta A, Alaverdyan M, Torgerson C, Ashe-McNalley C, Irimia A, Hong JY, Naliboff B, Tillisch K, Mayer EA. Multivariate morphological brain signatures predict patients with chronic abdominal pain from healthy control subjects. Pain. 2015;156(8):1545-54. Epub 2015/04/24. doi: 10.1097/j.pain.0000000000000196. PubMed PMID: 25906347; PMCID: PMC4504800.

Mayer EA, Tillisch K, Gupta A. Gut/brain axis and the microbiota. The Journal of clinical investigation. 2015;125(3):926-38. Epub 2015/02/18. doi: 10.1172/jci76304. PubMed PMID: 25689247; PMCID: PMC4362231.

Sanmiguel C, Gupta A, Mayer EA. Gut Microbiome and Obesity: A Plausible Explanation for Obesity. Current obesity reports. 2015;4(2):250-61. Epub 2015/06/02. doi: 10.1007/s13679-015-0152-0. PubMed PMID: 26029487; PMCID: PMC4443745.

2014

Gupta A, Kilpatrick L, Labus J, Tillisch K, Braun A, Hong JY, Ashe-McNalley C, Naliboff B, Mayer EA. Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences. Psychosomatic medicine. 2014;76(6):404-12. Epub 2014/07/09. doi: 10.1097/psy.0000000000000089. PubMed PMID: 25003944; PMCID: PMC4113723.

Hong JY, Kilpatrick LA, Labus JS, Gupta A, Katibian D, Ashe-McNalley C, Stains J, Heendeniya N, Smith SR, Tillisch K, Naliboff B, Mayer EA. Sex and disease-related alterations of anterior insula functional connectivity in chronic abdominal pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014;34(43):14252-9. Epub 2014/10/24. doi: 10.1523/jneurosci.1683-14.2014. PubMed PMID: 25339739; PMCID: PMC4205551.

Kilpatrick LA, Coveleskie K, Connolly L, Labus JS, Ebrat B, Stains J, Jiang Z, Suyenobu BY, Raybould HE, Tillisch K, Mayer EA. Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women. Gastroenterology. 2014;146(5):1212-21. Epub 2014/02/01. doi: 10.1053/j.gastro.2014.01.023. PubMed PMID: 24480616; PMCID: PMC4113508.

Labus JS, Dinov ID, Jiang Z, Ashe-McNalley C, Zamanyan A, Shi Y, Hong JY, Gupta A, Tillisch K, Ebrat B, Hobel S, Gutman BA, Joshi S, Thompson PM, Toga AW, Mayer EA. Irritable bowel syndrome in female patients is associated with alterations in structural brain networks. Pain. 2014;155(1):137-49. Epub 2013/10/01. doi: 10.1016/j.pain.2013.09.020. PubMed PMID: 24076048; PMCID: PMC4100785.

Labus JS, Dinov ID, Jiang Z, Ashe-McNalley C, Zamanyan A, Shi Y, Hong JY, Gupta A, Tillisch K, Ebrat B, Hobel S, Gutman BA, Joshi S, Thompson PM, Toga AW, Mayer EA. Irritable Bowel Syndrome in female patients is associated with alterations in structural brain networks. Pain. 2014; 155(1):137-49. PMCID: PMC4100785.

2013

Connolly L, Coveleskie K, Kilpatrick LA, Labus JS, Ebrat B, Stains J, Jiang Z, Tillisch K, Raybould HE, Mayer EA. Differences in brain responses between lean and obese women to a sweetened drink. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2013;25(7):579-e460. Epub 2013/04/10. doi: 10.1111/nmo.12125. PubMed PMID: 23566308; PMCID: PMC4114731.

Hong J-Y, Kilpatrick L, Labus JS, Gupta A, Jiang Z, Ashe-McNalley C, Stains J, Heendeniya N, Ebrat B, Smith S, Tillisch K, Naliboff B, Mayer EA. Patients with Chronic Visceral Pain Show Sex-Related Alterations in Intrinsic Oscillations of the Resting Brain. Journal of Neuroscience. 2013; 33(29):11994-12002. PMCID: PMC713732.

Jiang Z, Dinov ID, Labus J, Shi Y, Zamanyan A, Gupta A, Ashe-McNalley C, Hong JY, Tillisch K, Toga AW, Mayer EA.. Sex-Related Differences of Cortical Thickness in Patients with Chronic Abdominal Pain. PLOS ONE. 2013; 8(9):e73932. PMCID: PMC3764047.

Labus J, Gupta A, Gill HK, Posserud I, Mayer M, Raeen H, Bolus R, Simren M, Naliboff BD, Mayer EA. Randomised clinical trial: symptoms of irritable bowel síndrome are improved by a psycho-education group intervention. Alimentary Pharmacology Therapeutics. 2013; 37(3): 304-15. PMCID: PMC3829380.

*Labus JS, *Gupta A, Coveleskie K, Tillisch K, Kilpatrick L, Jarcho J, Feier N, Bueller J, Stains J, Smith S. Suyenobu B, Naliboff BN, Mayer EA. Sex Differences in Emotion-related Cognitive Processes in Irritable Bowel Syndrome and Healthy Control Subjects. Pain. 2013; 154(10):2088-99. PMCID: PMC4049231. *Equal Contributors