Why is Sex and Gender So Important in IBS?

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      Key Points:

      • IBS is a female predominant disorder of gut-brain interactions in which sex hormones contribute to its pathophysiology
      • Sex differences contribute to the clinical symptoms and treatment response
      • Sex differences exist in the peripheral and central pathophysiologic mechanisms underlying IBS, including visceral hypersensitivity, immune response, post-infection IBS, autonomic response and structural and functional alterations in the central nervous system.
      Research Highlights
      Gender,
      Irritable Bowel Syndrome,
      Lin Chang,
      SCORE,
      Sex Differences