The Laboratory of Vertebrate Functional Brain Mapping has over a decade of experience in imaging of the rodent brain, with expertise in behaviors in rodent models of pain, anxiety, brain injury, and anxiety, as well as in physiologic monitoring (ECG, EMG, EEG, cardiovascular function). The lab uses a variety of techniques in the analyses of the three-dimensional autoradiographic data sets of the rat and mouse brains, including region-of-interest analysis, statistical parametric mapping, as well as functional connectivity. A primary interest has been the development of new methods for functional brain imaging of rodent behaviors as they occur in freely moving animal in normal and pathological states. Ongoing projects examine activation of neural circuits and functional brain reorganization in rat models of visceral pain, traumatic brain injury, ‘Parkinson’s Disease’, and the serotonin transporter knockout mouse.
Wang Z, Ocampo MA, Pang RD, Bota M, Bradesi S, Mayer EA, Holschneider DP “Alterations in Prefrontal-Limbic Functional Activation and Connectivity in Chronic Stress-Induced Visceral Hyperalgesia”, PLoS ONE, 8(3):e59138, 2013, PMID:23527114
Holschneider DP, Guo Y, Wang Z, Roch M, Scremin OU, “Remote brain networks changes after unilateral cortical impact injury and their modulation by acetylcholinesterase inhibition” Journal of Neurotrauma, 30(11):907-919, 2013, PMID:23343118
Wang Z, Myers KG, Guo Y, Ocampo MA, Pang RD, Jakowec MW, Holschneider DP, “Functional reorganization of motor and limbic circuits after forced exercise training in a rat model of bilateral Parkinsonism”, PLoS ONE, 8(11), e80058, 2013, PMID:24278239
Holschneider DP, Wang Z, Pang RD, “Functional connectivity-based parcellation and connectome of cortical midline structures in the mouse: a perfusion autoradiography study”, Frontiers in Neuroinformatics, Jun 11;8:61. doi: 10.3389/fninf.2014.00061, 2014, PMID 24966831
Wang Z, Guo Y, Myers KG, Heintz R, Peng Y-H, Maarek J-MI, Holschneider DP “Exercise alters resting state functional connectivity of motor circuits in Parkinsonian rats,” Neurobiology of Aging, in press