UCLA SCOR is comprised of an Administrative Core and two Scientific Cores

CORE A: Administrative Core

Aim 1
Executive Committee-The Executive Committee function in an advisory capacity to the Center’s Director. The membership includes the Director (EA Mayer) and Co-Director (L Chang), the PI’s of each of the research projects, and the Core Directors. The principles under which the Center will operate will be established by the Director upon the advice of this committee.

Aim 2
Enrichment and Annual Research Meeting Planning Committee – This committee is responsible for continuing the highly successful annual research meeting, a day devoted to plenary and poster sessions highlighting the research activities of Center members

Aim 3
Education and Mentoring – One of the Center’s missions is to offer educational activities, programs and opportunities for all people associated with the Center. These activities are intertwined with the enrichment program and include single seminars, seminar series, mini symposia and mentoring.

CORE B: Neuroendocrine Measures Core

Aim 1
Offer resources for the analysis of ACTH (in the blood and adipose tissue of humans and rats), as well as cortisol (blood and adipose tissue of humans) and corticosterone (blood and adipose tissue of rats)

Aim 2
Provide high quality RNA, DNA and protein isolation services to Projects 1 and 2 for Real time PCR, ELISA or multiplex immunoassays and DNA methylation studies.

Aim 3
Provide consultation for generation of transgenic animals, over-expression of silencing shRNAs, and for design and testing of the appropriate vectors for the creation of the aforementioned models.

CORE C: Neuroimaging and Bioinformatics Core

The overall goal of the Core is to provide advanced services for design, analysis and interpretation of brain imaging data generated by Aim 3 of the SCOR, as well as provide these services for any neuroimaging project performed at the UCLA Center focusing on sex related differences of brain structure and function.

Aim 1
Design and set up of the imaging and psychophysiology protocols for UCLA SCOR and all brain imaging studies aimed at studying sex related brain differences

Aim 2
Monitoring and ensuring quality control of all data collection for these measures

Aim 3
Preprocessing and analysis of all imaging and psychophysiology measures for UCLA SCOR and all brain imaging studies aimed at studying sex related brain differences

Aim 4
Participation in interpretation and write up of results along with project PIs for UCLA SCOR and all brain imaging studies aimed at studying sex related brain differences.

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