Main Goal: To conduct preliminary analyses of resting state fMRI data pooled across several sites with NIH funding for Specialized Centers of Research (SCOR) on Sex and Gender Factors Affecting Women’s Health.

Who: SCOR neuroimaging sites at UCLA, Medical University of South Carolina, Charleston, and Yale University. Medical University of South Carolina, Charleston is the lead site. UCLA, in addition to contributing resting state fMRI scans, is using its expertise in developing and maintaining neuroimaging database repositories (www.painrepository.org).

Specific Aims:
Aim 1. Create organized, shareable dataset of resting state fMRI that has (a) strong representation of both males and females and (b) characterization of childhood adversity.
Aim 2. Compare analytical strategies to determine the relative sensitivity of the approaches in detecting sex differences in functional brain organization.
Aim 3. Determine altered functional connectivity and sex-specific profiles related to childhood trauma.

Progress: Currently, over 130 qualifying scans among the 3 contributing sites have been placed in the rapidly growing repository.

Center Sex
MUSC 39 males
8 females
Yale 23 males
25 females
UCLA 20 males
23 females

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