Nigel Bunnett was educated at Cambridge University where he was awarded a Ph.D. degree in 1981. He spent the next thirty years of his career on the West Coast of the United States, as a post-doctoral fellow at the University of California, Los Angeles, and then an Assistant Professor at the University of Washington, Seattle. In 1987 he joined the University of California, San Francisco, and he remained there for almost twenty five years, becoming Professor of Surgery and Physiology, Vice Chair of Surgery, and Director of the UCSF Center for the Neurobiology of Digestive Diseases. Nigel relocated to Monash University, Melbourne in 2011, where holds appointments as NHMRC Australia Fellow, Professor of Pharmacology and Medicine, and Deputy Director of the Monash Institute of Pharmaceutical Science.
Nigel’s research focuses on understanding the mechanisms of inflammation and pain, which underlie diseases of global relevance. He is particularly recognized for his work on defining the functions and regulation of G protein-coupled receptors and transient receptor potential ion channels, two major classes of cell-surface proteins that are essential for the transmission of inflammation and pain. Nigel’s work has been reported in ~300 research papers, reviews and chapters, and is funded by the NHMRC, ARC and NIH. His contributions have been recognized by awards including an Australia Fellowship, an NIH MERIT Award, the Novartis Neurogastroenterology Award, the Jansen Award for Basic Research in Gastroenterology, and the Victor Mutt Award for Research in Regulatory Peptides. Throughout his career Nigel has been committed to medical education, and he has received numerous awards in recognition of his dedication to teaching.
PubMed Link: http://www.ncbi.nlm.nih.gov/pubmed?term=Bunnett%20N
Murphy JE, Padilla BE, Hasdemir B, Cottrell GS, Bunnett NW. Endosomes: a legitimate platform for the signaling train. Proc Natl Acad Sci U S A, 106: 17615-17622, 2009.
Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW*, Corvera CU. The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest, 123: 1513-1530, 2013. * Corresponding author
Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW. Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev, 94: 265-301, 2014.
Jensen D, Halls M, Murphy JE, Canals M, Cattaruzza F. Lieu T, Poole DP, Koon H-W, Pothoulakis C, Bunnett NW. Endothelin-converting enzyme-1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals. J Biol Chem. In press.