The Center is comprised of 23 faculty members with a total annual research budget of over $ 5 M in 2010, based on federal grants from the NIDDK, the ORWH and NCCAM. The Program in Mind Body research has been generously supported by the Oppenheimer Family Foundation.
Ongoing Research Support
R01 DK048351 Mayer (PI) 09/30/96 – 06/31/13
Perception and Modulation of Visceral Sensations
The major goals of this project are: 1) Identify neurobiological endophenotypes in IBS patients. 2) Correlate these endophenotypes with gene polymorphisms.
P50 DK064539 Mayer (PI) 09/30/02 – 08/31/12
Women’s Health and Functional Visceral Disorders Center
The main focus of the Center is the identification of sex-related factors that play a role in the development, clinical manifestation and treatment response of two common visceral pain syndromes, e.g., irritable bowel syndrome (IBS) and interstitial cysitits (IC). The Center has 4 Projects (2 clinical, 2 basic) and 2 Scientific Cores.
U01 DK082370 Mayer/Rodríguez (PI’s) 07/01/08 – 06/30/13
Brain Bladder Interactions in IC/PBS
This grant aims to characterize the interactions of biological and environmental vulnerability factors to shape behavioral and neurobiological endophenotypes, and ultimately clinical phenotypes in interstitial cystitis/painful bladder syndrome (IC/PBS). The grant has 2 Projects (Epidemiology study, Brain Imaging study) which are part of several transMAPP protocols.
R24 AT002681 Mayer (PI) 09/15/04 – 07/31/11
Mind/Brain/Body Interactions in Stress-Related Disorders (NIH Center Infrastructure)
The goal of this infrastructure grant is to develop 4 research cores (Health Outcomes, Neuroimaging, Animal Models, Psychophysiology and Pain Assessment) to provide novel, cutting edge expertise and technologies to UCLA investigators interested in the study of mind brain body interactions. After the full build up of the cores, there will be a Pilot and Feasibility program for years 3-5 of the grant with 4 annual awards. These projects will utilize the resources of the cores as well as the expertise of the involved faculty. In addition, a career development program in form of a Named New Investigator award is included, as well as several developmental and public infrastructure components.
Physiological Characteristics of Traditional Chinese Medicine-Based IBS subgroups
R21 AT003221 Naliboff (PI) 09/30/06 – 08/31/09
The goals are: 1) To characterize distinct pathophysiological patterns in major TCM-based subgroups of IBS; and 2) To identify selected symptom items which are predictive of major TCM subgroups.
A Randomized, Comparative, Mechanistic Trial of Iyengar Yoga vs Therapeutic Walking For Irritable Bowel Syndrome
Foundation Grant Naliboff and Shapiro (PIs) 1/1/10 – 12/30/12
Funding: Oppenheimer Family Foundation and Marcled Foundation
The goal of this study is to provide a comprehensive evaluation of the efficacy of Iyengar Yoga compared to the effects of a walking program in patients suffering from IBS. In addition to symptom measures, outcomes will include laboratory measures of physiological stress responses and pain sensitivity.
Treatment of Pain and Fear in Irritable Bowel Syndrome
R01 NR007768 Naliboff (PI) 07/01/02 – 06/30/07
Funding: NIH/National Institute of Nursing Research
The major goals of this randomized clinical trial are: 1) To compare symptom and Quality of Life responses in IBS patients to three treatment conditions: a novel behavioral treatment using exposure and directed attention, a stress management treatment, and an educational intervention. 2) To compare the treatments on visceral sensitivity, hypervigilance and autonomic responses, and 3) To compare the treatments on central responses to visceral related stimuli using functional brain imaging.
NIH/NIAMS R01 AR46122-01 Chang (PI) 02/04/06 – 01/31/12
Neuroendocrine Alterations in Fibromyalgia and IBS
This study assesses the role of enhanced pain amplification mechanisms of heightened attention and symptom-specific anxiety in IBS and fibromyalgia.
M01-RR00865 Levey (PI) Chang(Co-I) 12/01/06 – 06/30/11
General Clinical Research Center
The goal of this project is to facilitate and enable the access and conduct of high-quality traditional and cutting edge, clinical research by providing space, infrastructure, and resources including core laboratory, biostatistical services and training opportunities.
P30 DK 41301 Rozengurt (PI) 12/01/04 – 11/30/14
Chang (Co-Director, Human Studies Core)
CURE: Digestive Diseases Research Core Center
The CURE: Digestive Diseases Research Core Center is composed of a cohesive group of physicians and basic scientists with strong independent peer-reviewed grant-supported research programs in the biology of the gut, with special emphasis upon regulation of mucosal cell function, gut neuroscience and signal transduction mechanisms.
1 U01 AR057936-01 Khanna/Spiegel (Co-PI) Chang (Co-I) 10/01/09-07/31/13
Development and Initial Validation of PROMIS GI Distress Scale.
The goals of this project are to develop a GI Distress item pool and evaluate its psychometric properties in three patient groups: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and scleroderma.
1K23DK073451 Tillisch (PI) 04/01/06 – 03/31/12
Central and Peripheral Autonomic Responses in IBS
This Mentored Career Development Award is designed to provide the skills to integrate the rapidly emerging techniques of neuroimaging, autonomic nervous system analysis, and clinical skills in gastroenterology to perform cutting edge translational research in functional gastrointestinal disorders.
NU271 (Danone) Tillisch (PI) 10/08 – 01/12
An fMRI Study of Affective Changes Associated with Four Weeks Consumption of a Fermented Dairy Product in Healthy Women
R03 DK084169 Labus, J (PI) 09/01/09-08/30/11
Brain mechanisms underlying selective attention in IBS
This R03 tests the general hypothesis that central pain amplification in IBS is in part related to impairment in brain mechanisms responsible for regulating attention. The proposed studies are an extension of my K08 award that aims to identify the neuroanatomical substrates of the cognitive, behavioral, affective and physiologic alterations in IBS patients. This research will provide preliminary data for a planned R01 grant proposal focused on delineating the mechanism of PFC dysfunction in IBS.
K08 DK071626 Labus (PI) 07/01/06 – 06/30/11
Effective Connectivity of Central Response in IBS
This Mentored Clinical Scientist Development training plan involves the acquisition, development and application of novel quantitative methods such as effective connectivity modeling and individual growth curve modeling for fMRI and pyschophysiological data and includes coursework and mentored training in neuroscience, neurobiology of brain-gut interactions, advanced biostatistics, neuroengineering, and clinical research in IBS.
K01DK085133 Kilpatrick (PI) 03/01/11 – 03/01/16
Sex-specific genetic architecture of irritable bowel syndrome
The overall goal of this project is to provide new information on sex-specific genetic influences involved in the pathophysiology of IBS pain. The findings should have significant implications for translational research and the development of personalized treatments, thereby improving health care for IBS patients.